The Da Varano family ruled Camerino from the mid thirteenth century until 1539. During the Giulio Cesare da Varano’s rule (1464-1502), Camerino enjoyed a flourishing period. He showed his grandeur in his military enterprises. There are actually many fortresses surrounding Camerino and its neighbourhood: the Fortress Borgesca (Camerino), the Fortress Varano (Sfercia di Camerino) the Fortress Aiello (Castelraimondo), the Castle of Lanciano (Castelraimondo) and Beldiletto (Pievebovigliana).
The Ducal Palace of Camerino is among the notable buildings of civil architecture built by the Da Varano family, and is now home to the University. In Esanatoglia, the Varano family built a fortified residence in the fourteenth century (now the Palazzo Comunale, or Municipal Building).
Following an earthquake in 1997, restoration work was carried out which unearthed a unique pictorial cycle of jousters on horseback. The Da Varano family also founded religious buildings such as the Monastery of Santa Maria Nova in Camerino
, which was later dedicated to St. Clare
the Temple of the Annunciation,
built between 1493 and 1508 where, according to legend, a visual representation of Our Lady took refuge, fleeing from the house of a blasphemer.